General Cell Lines and Cell Cultures
ATCC Daudi-Luc2; Burkitt's Lymphoma; Human (Homo Sapiens)
For-profit organizations: For every order of this item, you must provide a signed Material Transfer Agreement Addendum for Screening Application. We cannot ship this item until we receive this addendum. The person signing the addendum as the principal investigator must match the end user as listed on the applicable sales order for the item.Email the signed addendum to SalesPermits@atcc.org with a reference to both your account and sales order numbers. Once received, your addendum will be reviewed, and this item will be released for shipment if all requirements are met. Additional fees may apply if this product is being used for a screening use (ATCC ACS-2103F), and these fees will be applied after your order is confirmed. If you need assistance with your order, please contact our Customer Care team.
IPHASE PHARMA SERVICES LLC Plateable Cynomolgus Monkey Hepatocytes,Male,5million
Primary Hepatocytes are isolated from human and animal liver tissues. It's a tool for cytochrome P450 induction, Hepatotoxicity assays and siRNA devlivery, Transfection, Sandwitch model, 3D Primary Hepatocyte Spheroid Model (Three-Dimensional Liver Culture system) and organoids culture. IPHASE provides both suspension and plateable Hepatocytes, animal or human and speical species includes: cat(feline), Guinea pig, BALB/c Nude, Ferret, Gerbil customize hepatocytes. Plateable Hepatocytes need to be used in conjunction with Thaw medium, Plateable medium, Maintenance medium and Collagen Coated Plate.These products require shipment in LN2 container therefore customer need to return the container.
Eurofins Discoverx Ready-to-Assay CXCR6 Chemokine Receptor Frozen Cells, 2 Vials of Cells. (HTS054RTA)
The Ready-to-Assay CXCR6 Chemokine Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. CXCL16) based activation of CXCR6 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CXCR6 alongside exogenous levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of CXCR6, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx PathHunter CHO-K1 rOPRM1 β-Arrestin Cell Line, 2 vials. (93-0494C2)
The PathHunter rOPRM1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. DADLE) based activation of rOPRM1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged rOPRM1 and EA-tagged β-Arrestin-2. Activation of rOPRM1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Rat version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx cAMP Hunter CHO-K1 MTNR1B Gi Cell Line, 2 vials. (95-0056C2)
The cAMP Hunter MTNR1B Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. melatonin) based activation of MTNR1B GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type MTNR1B, a naturally Gi/Go coupled GPCR. Upon activation of MTNR1B, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter U2OS mINSRa Functional Assay, 2 vials. (93-1015C3)
The PathHunter U2OS mINSRa Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated mINSRa dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged mINSRa and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of the protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Eurofins Discoverx PathHunter U2OS BMPR1B/ACVR2A Dimerization Cell Line, 2 vials. (93-1010C3)
The PathHunter BMPR1B/ACVR2A Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. BMP-6) induced dimerization of BMPR1B/ACVR2A receptors. This product uses EFC technology. The cell line included overexpresses BMPR1B target protein fused to PK alongside ACVR2A target protein fused to EA. Upon ligand-induced dimerization of BMPR1B/ACVR2A, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Eurofins Discoverx PathHunter CHO-K1 ADRA1B β-Arrestin Cell line, 2 vials. (93-0274C2)
The PathHunter ADRA1B cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. epinephrine and norepinephrine) based activation of ADRA1B GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged ADRA1B and EA-tagged β-Arrestin-2. Activation of ADRA1B stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 ADRB1 β-Arrestin Cell line, 2 vials. (93-0488C2)
The PathHunter ADRB1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. isoproterenol) based activation of ADRB1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged ADRB1 and EA-tagged β-Arrestin-2. Activation of ADRB1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC NALM6, clone G5; Lymphoma; Human (Homo sapiens)
NALM6, clone G5 is a lymphocyte-like that was isolated from the peripheral blood of a 19-year-old, male patient with acute lymphoblastic leukemia. This cell line was deposited by RS (Treichel) Salter (Oberlin College) in 2010.
Eurofins Discoverx PathHunter CHO-K1 CCRL1 β-Arrestin Cell Line, 2 vials. (93-0946C2)
The PathHunter CCRL1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CCL19/MIP-3β) based activation of CCRL1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CCRL1 and EA-tagged β-Arrestin-2. Activation of CCRL1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx cAMP Hunter CHO-K1 PPYR1 (NPY4R) Gi Cell Line, 2 vials. (95-0087C2)
The cAMP Hunter PPYR1 (NPY4R) Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. pancreatic polypeptide, peptide YY) based activation of PPYR1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type PPYR1, a naturally Gi/Go coupled GPCR. Upon activation of PPYR1, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CXCR4 Total Internalization U2OS Cell Line, 2 vials. (93-0890C3)
The PathHunter CXCR4 Total Internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of CXCR4 via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged CXCR4 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the CXCR4 receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC SK-MEL-24; Malignant Melanoma; Human (Homo sapiens)
SK-MEL-24 is a cell line exhibiting stellate morphology that was isolated from the skin of a 67-year-old, White male patient with melanoma. This product has applications in cancer research and immuno-oncology.